Psoriasis, a chronic inflammatory skin condition, poses substantial morbidity and psychological burden due to its complex pathogenesis. Biologics, novel drugs targeting specific inflammatory pathways, are increasingly pivotal in psoriasis management, boasting a reduced side effect profile compared to traditional therapies albeit with higher treatment costs. This handbook comprehensively covers existing biologics, serving as a convenient reference for practitioners and post-graduate students. By encapsulating crucial details on these therapeutic compounds, the authors facilitate informed decision-making and enhance clinical understanding, thereby contributing to improved patient care and outcomes in the management of psoriasis.