The practical lab manual for Genetics & Cell Biology serves as a comprehensive handbook for B.Sc. students in Indian universities, aligning with the NEP-20 curriculum. It covers essential topics such as population genetics and karyotypes, alongside hands-on studies of mitosis and meiosis. Featuring both solved and unsolved problems, the manual is designed for easy understanding and updated knowledge. The author thanks colleagues and family for their support in creating this valuable resource for students.